![]() The two review authors (XL, CZ) were independently responsible for scanning titles and abstracts, selecting studies, reading full reports, extracting data, and assessing the quality of studies these steps were performed in duplicate by each of these authors. The aim of this study was to summarize and assess the efficacy, different treatment protocols (formulation, dosage, and duration), and safety of nystatin in different patient populations with oral candidiasis by a meta-analysis and systematic review. 5, 21– 23 Up to now, there is no consensus on the formulation, dosage, or treatment duration of nystatin in the treatment of oral candidiasis. 18, 20 Treatment duration can vary from 1 or 2 to 4 weeks. 16– 19 The common recommended dose for topical use of nystatin is 200,000–600,000 IU qid for children and adults, and 100,000–200,000 IU qid for newborns and infants. Further, nystatin also plays an important role in the prophylaxis of oral and systemic candidiasis in full-term and premature newborns, infants, and immunocompromised patients (eg, AIDS patients, cancer patients, and organ transplant recipients), as it is associated with a low incidence of drug interactions and acceptable costs, especially in developing countries. 5 Therefore, the topical use of nystatin is considered the most common route of administration in dentistry, as systemic exposure is minimal. 11– 15 Nystatin is not absorbed from gastrointestinal tract when orally administered. Nystatin is a membrane-active polyene macrolide produced by Streptomyces noursei strains and is available in various forms, such as oral suspension, topical cream, and oral pastille. 7, 8 Topical antifungal agents, such as nystatin, amphotericin B, miconazole, and clotrimazole, are recommended typically as the first-line treatment for uncomplicated cases of oral candidiasis. 3, 6 However, numerous drug interactions and decreased susceptibility of species other than Candida albicans toward azoles limit the application of systemic antifungal agents. 3 Systemic antifungal agents, including triazoles, fluconazole, and itraconazole, are appropriate for patients who do not respond to or are intolerant to topical treatment and those at high risk of developing systemic infections. Various topical and systemic agents are currently available for the treatment of oral candidiasis. 3– 5 Elimination of the predisposing factors is an important strategy in treating oral candidiasis. 1, 2 It has been associated with multiple host risk factors, including impaired salivary gland function, denture wearing, oral mucosa disruption, drug use (long-term administration of broad-spectrum antibiotics, corticosteroids, antidepressants, antineoplastic, drugs, and immunosuppressant), age (common in neonates and the elderly), endocrine alterations (diabetes mellitus, pregnancy, renal failure, and hyperthyroidism), dietary factors (high-carbohydrate diet and iron-deficiency anemia), cancer, and HIV infection. Most doctors recommend that you continue to use the drops for two days after your symptoms have gone - a typical course of treatment will last around seven days.Oral candidiasis, which is the most common human fungal infection, is characterized by an overgrowth of Candida species in the superficial epithelium of the oral mucosa.Try to take the correct number of doses each day but do not take two doses at the same time to make up for a missed dose. If you forget to use the drops, have a dose as soon as you remember.This is to prevent the medicine from being washed out of your mouth too soon by anything you eat or drink. ![]() It is recommended that you use the drops after mealtimes.The longer the medicine is in contact with the site of infection the better. Swish the suspension around your mouth a little and then keep it on the affected areas for as long as possible before you swallow. Use the dropper to drop the liquid inside your mouth near to the affected areas but try not to touch your mouth with the dropper as you do this. Shake the bottle well before you use the drops. ![]() Your doctor will tell you how many droppersful (ml) to use for each dose. Space the doses evenly throughout the day. Use the suspension exactly as your doctor tells you to. ![]() If you have been given any additional information by your doctor, please read this also. It will give you more information about how to use nystatin drops.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |